President Hidetoshi Arima

Welcome to the Homepage of the Society of Cyclodextrins, Japan (SCDJ). This site is packed with helpful information and is designed to assist in the planning of further studies related to cyclodextrins. I sincerely hope that you find the content both informative and practical, and I wish you every success in your investigations.

Cyclodextrin is a cyclic oligosaccharide composed of several glucose units. Despite the unusual conformation, which resembles a bottomless bucket, cyclodextrins exert a range of potentially useful functions. Schardinger first described a technique for separating and purifying cyclodextrins in 1903, and they have since been utilized in both basic and applied research, such as water-solubilization by including "guest" molecules, enzyme modeling and chiral recognition. Chemical modification of cyclodextrins has been extensively conducted and numerous derivatives have been described, and various new functions are also expected to be identified.

In the food industry, the effective utilization of cyclodextrin for the sixth nutrient, dietary fiber, phytochemical and human chemicals such as coenzyme Q10, α-lipoic acid and L-acetyl carnitine is also attracting attention. In the pharmaceutical industry, not only the use of cyclodextrin as inclusion complexes with drug substance drug (API) and as excipients, but also the utilities of cyclodextrins themselves as an API.

In the field of Supramolecular Chemistry, cyclodextrins played a key role in the understanding of molecular imprinting as an antibody-antigen reaction, chromophoric sensing guest-recognition/detection, and rotaxane and catenane as a molecular device of the molecular machine. In addition, the practical application of a slide-ring material for vehicle body construction that has both high rigidity and high toughness has been advancing towards the 2020 Tokyo Olympics. In nano-science and nano-technology, cyclodextrins are expected to become prominent bionano-materials as soft materials. Furthermore, cyclodextrins are both biodegradable and biocompatible, and this allows their use in biological systems while minimizing their ecological impact.

Japan has been the international center of cyclodextrin research since Prof. Kouki Horikoshi described the mass production of cyclodextrin in 1988. More published research papers on cyclodextrins, including original scientific papers, have originated in Japan than in any other country. Those researchers involved in the study of cyclodextrins have developed into a "cyclodextrin family", which is an organization based on mutual communication and cooperation. I hope that cyclodextrin researchers will continue moving towards the goal of Green Sustainable Chemistry by promoting the use of cyclodextrins worldwide.

If you are not members of SCDJ, join SCDJ, attend activities of SCDJ, and find new things about CDs.