President Keiko Takahashi

Welcome to the Homepage of the Society of Cyclodextrins, Japan (SCDJ). This site is packed with helpful information and is designed to assist in the planning of further studies related to cyclodextrins. I sincerely hope that you find the content both informative and practical, and I wish you every success in your investigations.

Cyclodextrin is a cyclic oligosaccharide composed of several glucose units. Despite the unusual conformation, which resembles a bottomless bucket, cyclodextrins exert a range of potentially useful functions. Schardinger first described a technique for separating and purifying cyclodextrins in 1903, and they have since been utilized in both basic and applied research, such as water-solubilization by including "guest" molecules, enzyme modeling and chiral recognition. Chemical modification of cyclodextrins has been extensively conducted and numerous derivatives have been described, and various new functions are also expected to be identified.

In the field of Supramolecular Chemistry, cyclodextrins played a key role in the understanding of molecular imprinting as an antibody-antigen reaction, chromophoric sensing guest-recognition/detection, and rotaxane and catenane as a molecular device of the molecular machine. In nano-science and nano-technology, cyclodextrins are expected to become prominent bionano-materials as well as fullerene and carbon nano-tubes. Cyclodextrins are both biodegradable and biocompatible, and this allows their use in biological systems while minimizing their ecological impact.

The pharmaceutical applications of cyclodextrins are particularly exciting. Papers describing the potential use in drug delivery were published at the 2002 International Symposium of Cyclodextrins in Reykjavik where Prof. Kaneto Uekama gave the keynote lecture in front of 300 researchers from 32 countries. Cyclodextrins, for example, have been used in gene therapy trials.

Japan has been the international center of cyclodextrin research since Prof. Kouki Horikoshi described the mass production of cyclodextrin in 1988. More published research papers on cyclodextrins, including original scientific papers, have originated in Japan than in any other country. Those researchers involved in the study of cyclodextrins have developed into a "cyclodextrin family", which is an organization based on mutual communication and cooperation. I hope that cyclodextrin researchers will continue moving towards the goal of Green Sustainable Chemistry by promoting the use of cyclodextrins worldwide.

If you are not members of SCDJ, join SCDJ, attend activities of SCDJ, and find new things about CDs.